Cellator’s High-Throughput Expansion System: Accelerating Bioprocessing Efficiency
The demand for biologics, such as cell and gene therapies, recombinant proteins, and vaccines, has grown exponentially in recent years. These products offer promising treatment options for a wide range of diseases, including cancer, diabetes, and autoimmune disorders, but their production is complex and time-consuming, requiring multiple steps of cell culture and bioprocessing. To meet the growing demand for biologics, the biopharmaceutical industry needs to develop more efficient and scalable manufacturing processes that can accelerate product development and reduce costs. Cellerator’s High-Throughput Expansion System is a promising solution that can help biomanufacturers to achieve their goals.
The High-Throughput Expansion System is a novel platform for cell expansion and optimization, designed to streamline the manufacturing process from research to commercial production. The system uses an innovative microfluidic technology that enables high-density and continuous cell culture in a small footprint, reducing the need for manual handling and simplifying the workflow. The system can be customized to accommodate various cell types, including adherent cellerator and suspension cells, and it can be integrated with downstream processes such as transfection, purification, and formulation.
One of the key advantages of the High-Throughput Expansion System is its ability to increase cell yield and biomass in a short time. The microfluidic channels provide a controlled and oxygen-rich environment that enhances cell growth and metabolism, resulting in higher cell density and viability. The system can generate up to 10^9 cells from a single well in just a few days, which is several times higher than traditional methods, such as T-flasks or roller bottles. The increased yield not only reduces the time and resources required for cell expansion but also improves the product quality and consistency due to the reduced variability in cell growth and morphology.
Another benefit of the High-Throughput Expansion System is its scalability and parallelization capabilities. The system can accommodate up to 96-well plates and can be automated to run multiple experiments in parallel, allowing researchers to optimize their cell culture conditions and media formulations quickly. The system’s modular design also allows for easy integration with other bioprocessing equipment, such as bioreactors or harvesters, for upstream and downstream processing.
The High-Throughput Expansion System also offers a more cost-effective and sustainable approach to cell culture. The system’s small footprint and high yield mean that the same volume of cells can be produced using less space and fewer resources, such as media, serum, and CO2. The reduced reliance on animal-derived products also aligns with the growing trend towards animal-free and chemically-defined cell culture media, which can improve the product quality and safety.
Overall, Cellerator’s High-Throughput Expansion System is a promising solution for accelerating bioprocessing efficiency and bringing biologics to the market faster and cheaper. The system’s innovative microfluidic technology, high yield, scalability, and sustainability make it an attractive option for both research and industrial applications. As the biopharmaceutical industry continues to evolve, the High-Throughput Expansion System will play a critical role in enabling faster and more efficient product development, reducing the manufacturing costs, and improving patient access to life-saving therapies.